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292 – Gene Editing with CRISPR/Cas

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CRISPR is a family of DNA sequences in bacteria and archaea that are a part of these organisms’ cellular defense system. A recent discovery showed how this mechanism can be used to edit genes much more easily than legacy methods. In this episode I chat with Sam Sternberg about the naturally occuring CRISPR systems, how they work, and how CRISPR together with its associated enzymes can be used to cut, and subsequently, edit, DNA. We conclude the episode with an outlook on the potential use in medicine.

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291 – Flying in the Papuan Bush



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(average: 4.76)
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I chat with Daniel Geaslen about bush flying. His (at this time, former) job is to fly Kodiak turbo props for Mission Aviation Fellowship in Papua Indonesia, supplying remote villages. We cover the airplane, the missions, as well as the flying itself, with a particular focus on weather and challenging airfields.

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289 – Music Production at Sandlane Studios



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A few years ago, I interviewed Arjen Lucassen about his wonderful music and how he makes it; obviously, I am a big fan! Recently, his Ayreon universe was performed live on stage and I was blown away. I decided I had to talk the the guy behind the live shows, Joost van den Broek. Luckily he agreed. So I visited him in his studios and we talked about music production and arrangement in general, and specifically for the Ayreon live shows.

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288 – Flight Research at NASA Armstrong, Part 3: Historic



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(average: 4.62)
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In this episode I talk with NASA Armstrong’s chief scientist Al Bowers about the research projects he has been involved in during his long career at NASA. We cover deep stall research with a Schweizer sailplane, high-alpha flight and thrust vectoring with the X-29, X-31 and F-18 HARV, aero-tow of fast jets with the F-106, supercritical wings with the F-8, as well as space related projects using the SR-71 and the X-30. This is one of my favourite episodes of all time, since it is a bit of trip down memory lane for me personally, and Al perfectly hits the sweet spot between recounting facts and telling anecdotes.

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286 – Software Analog Effects

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(average: 4.47)
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Effects devices are essential for electric guitars and keyboards because they shape sound and make it interesting; many classic devices exist. However, those are rare and/or expensive, plus, even if they are not, carrying them around on a tour costs money. This is why these hardware devices are simulated in software, and distributed as plugins for audio software. Native Instruments is a manufacturer of such software analog effects packages. In this episode I chat with one of their engineers, Julian Parker, about how this software simulation of the electronic hardware is done.

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