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292 – Gene Editing with CRISPR/Cas

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CRISPR is a family of DNA sequences in bacteria and archaea that are a part of these organisms’ cellular defense system. A recent discovery showed how this mechanism can be used to edit genes much more easily than legacy methods. In this episode I chat with Sam Sternberg about the naturally occuring CRISPR systems, how they work, and how CRISPR together with its associated enzymes can be used to cut, and subsequently, edit, DNA. We conclude the episode with an outlook on the potential use in medicine.

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291 – Flying in the Papuan Bush



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I chat with Daniel Geaslen about bush flying. His (at this time, former) job is to fly Kodiak turbo props for Mission Aviation Fellowship in Papua Indonesia, supplying remote villages. We cover the airplane, the missions, as well as the flying itself, with a particular focus on weather and challenging airfields.

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290 – Langs Biogas-Kraftwerk



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Vor ein paar Wochen habe ich Ernst-Günther und Matthias Lang auf ihrem Hof und Biogas-Kraftwerk besucht. Wir haben uns unterhalten über den Verarbeitungs- und Energiegewinnungsprozess, die Integration und Synergien mit der Landwirtschaft sowie Aspekte der Wirtschaftlichkeit und der Unterstützung erneuerbarer Energien in Deutschland generell.

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289 – Music Production at Sandlane Studios



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A few years ago, I interviewed Arjen Lucassen about his wonderful music and how he makes it; obviously, I am a big fan! Recently, his Ayreon universe was performed live on stage and I was blown away. I decided I had to talk the the guy behind the live shows, Joost van den Broek. Luckily he agreed. So I visited him in his studios and we talked about music production and arrangement in general, and specifically for the Ayreon live shows.

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288 – Flight Research at NASA Armstrong, Part 3: Historic



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In this episode I talk with NASA Armstrong’s chief scientist Al Bowers about the research projects he has been involved in during his long career at NASA. We cover deep stall research with a Schweizer sailplane, high-alpha flight and thrust vectoring with the X-29, X-31 and F-18 HARV, aero-tow of fast jets with the F-106, supercritical wings with the F-8, as well as space related projects using the SR-71 and the X-30. This is one of my favourite episodes of all time, since it is a bit of trip down memory lane for me personally, and Al perfectly hits the sweet spot between recounting facts and telling anecdotes.

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