174 – Stem Cells
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Guest: Derrick Rossi Host: Markus Voelter Shownoter: Tim Jurik
Stem cells are an important part of today’s medical practice, and their importance will grow in the future based on research conducted today. One of the researchers in Derrick Rossi of Harvard and the Boston Children’s Hospital. In the episode we introduce the different kinds of stem cells and their role in the body and in medical treatments. We then discuss some clinical use cases as well as current research (in general and in Derrick’s group).
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What are stem cells
00:08:46Differentiated cell | Embryonic stem cell | Genes and DNA | Epigenome | Histone | Nucleosome | Watson and Crick
Pluripotent stem cells, Pancreatic beta cells, diabetes
00:56:50Stem cell use in research, ethical debate regarding embryonic stem cells, comparison to iPS
00:59:00Clinical uses and clinical trials
01:18:27Macular degeneration | Immune privilege | Graft vs tumor | Graft vs host | ViaCyte pancreas study | UK heart study | Parkinson's disease
Derek's work - blood forming stem cells and gene editing discussion
01:41:05Translational research | CRISPR | Zinc-finger Nuclease gene repair | Gene therapy
Wrap up
1:55:31
Ending credits
2:01:35
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I really enjoyed this podcast and the insights provided into stem cell research. I find medical research fascinating. Dr. Rossi did a great job explaining complex science in a way a business person can understand. Since both my kids have pursued science careers it helps me understand their world. I love the long format with a guided interview but plenty of room for the guest to explore.
Very nice episode! I was very surprised to hear for the first time of the IPS cells. What a wonderful discovery :-)